Lepirudin

Specification

• Cat#: THP-0082
• Product Name: Lepirudin
• Cas No: 138068-37-8
• Description: The product is identical to natural hirudin except for substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63. It is produced via yeast cells.
• Sequences: LVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ
• Molecular Weight: 6963.425 Da
• Source: Yeast
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C287H440N80O110S6
• Endotoxin: <0.001 EU per 1 μg by the LAL method
• Application: For the treatment of heparin-induced thrombocytopenia.
• Concentration: 50mg/ml
• Publication: Generation of a Universal Human Complement Source by Large-Scale Depletion of IgG and IgM from Pooled Human Plasma (Frances Alexander, Emily Brunt, Holly Humphries,et al.) (Bacterial Vaccines) (2021).
  

Pharmaceutical Information

• Pharmaceutical Application: Lepirudin
• Targets: Target 1. Prothrombin