Cat# : THP-0235
|THP-0235||Interleukin-6 (IL-6)||June 05, 2023||1 vial||$3,998.00||
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|Product Name:||Interleukin-6 (IL-6)|
|Description:||Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.|
|Sequences:||PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM|
|Molecular Weight:||20.9 kDa|
|Introduction:||IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells.|
|Purity:||≥ 98% by SDS-PAGE gel and HPLC analyses.|
|Biological Activity:||The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10＾7units/mg.|
|Applications:||IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses.|
|Examples of Clinical Use:||Regulating immune and inflammatory responses.|
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