IFN-Omega 1 (IFNW1)

Specification

• Cat#: THP-0253
• Product Name: IFN-Omega 1 (IFNW1)
• Description: IFN-Omega 1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19.9kDa. The IFN-Omega 1 is purified by proprietary chromatographic techniques.
• Sequences: MCDLPQNHGL LSRNTLVLLH QMRRISPFLC LKDRRDFRFP QEMVKGSQLQ KAHVMSVLHE MLQQIFSLFH TERSSAAWNM TLLDQLHTGL HQQLQHLETC LLQVVGEGES AGAISSPALT LRRYFQGIRV YLKEKKYSDC AWEVVRMEIM KSLFLSTNMQ ERLRSKDRDL GSS.
• Species: Human
• Molecular Weight: 19.9kDa
• Source: E. coli
• Introduction: IFN-Omega 1 is a type I IFN, that can be induced by virus-infected leukocytes. Type I IFN family members, which include IFN-alpha, IFN-beta, and IFN-omega, signal through IFNAR-1/IFNAR-2 receptor complex, and wield antiviral and antiproliferative activities. IFNW1 exhibits about 75% sequence homology with IFN-a, and contains 2 conserved disulfide bonds, which are essential for full biological activity.
• Purity: >95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Biological Activity: The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is < 0.01 ng/ml, corresponding to a specific activity of > 100,000,000 units/mg.
• Reconstitution: It is recommended to reconstitute the lyophilized IFNW1 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Application: Signal through IFNAR-1/IFNAR-2 receptor complex, and wield antiviral and antiproliferative activities

Related Reading

Background of IFNW1

IFNW1 protein, also known as interferon ω- Interferon Omega-1 is a member of the interferon family. Interferons are a multifunctional protein that can inhibit virus replication and cell proliferation, including three main types: α、β and ω。 IFNW1 is an interferon ω A member of the family that produces cells mainly in birds and reptiles, while IFNW1 in mammals produces a relatively limited range of cells.

Function of IFNW1

The main function of IFNW1 is to regulate the immune system, enhance the natural immune function of the body, and resist the invasion of viruses and other microorganisms. Another important role of IFNW1 is to regulate cell proliferation and apoptosis, which has inhibitory and promoting effects on tumors, depending on the type and state of the tumor.

IFNW1 related signaling pathway

The signaling pathway of IFNW1 is mainly initiated by binding to specific cell membrane receptors. IFNW1 can combine with PARP-14 and PA28 γ and other auxiliary proteins to enhance the activity of interferon. IFNAR2 is the main receptor of IFNW1, and its complex formed by binding to the IFNAR1 subunit can activate the downstream JAK-STAT signaling pathway. In addition, some IRF signaling pathways and NUCLEOLIN signaling pathways involving RIG-I like receptors are also involved in IFNW1 signaling transduction.

IFNW1 related diseases

The role of IFNW1 in diseases is mainly reflected in antiviral and immune regulation. IFNW1 can resist the invasion and replication of a variety of viruses, such as avian influenza virus, novel coronavirus, hepatitis B virus, etc. The overexpression of IFNW1 is closely related to the occurrence and development of certain pathological diseases such as autoimmune diseases and cancer.

The applications of IFNW1 in medicine

The potential application of IFNW1 in medicine is mainly reflected in two aspects. On the one hand, IFNW1 has a natural inhibitory effect on viral infection, and therefore has the potential to become a new target for antiviral drugs. On the other hand, IFNW1 has inhibitory and promoting effects on certain types of tumors, which may become a new method and means of treating cancer.

List of IFNW1 related drugs under research

IFNW1 related drugs in research mainly include two categories: one is IFNW1 itself or its analogues, mainly used to treat viral infections and certain types of cancer; Another type is IFNW1 receptor or signaling pathway related drugs, mainly used to regulate the IFNW1 pathway and improve the sensitivity of tumor cells to IFNW1. At present, these drugs are in the research and development stage, and further clinical trials and validation are needed before clinical application.

In summary, IFNW1 is an important member of the interferon family, with regulatory and antiviral effects on the immune system. However, the overexpression of IFNW1 is associated with the occurrence and development of certain diseases. The potential applications of IFNW1 in medicine include antiviral therapy and cancer treatment, and more research and validation are needed for related drugs under development.