Coagulation factor VIIa Recombinant Human

Specification

• Cat#: THP-0060
• Product Name: Coagulation factor VIIa Recombinant Human
• Cas No: 102786-61-8
• Description: Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. The product is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
• Sequences: ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
• Species: Human
• Molecular Weight: 45079.1 Da
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C1972H3076N560O597S28
• Endotoxin: <0.001 EU per 1 μg of the protein by the LAL method
• Biological Activity: 400KIU
• Application: For treatment of hemorrhagic complications in hemophilia A and B

Pharmaceutical Information

• Pharmaceutical Application: Coagulation factor VIIa Recombinant Human
• Targets: Target 1. Coagulation factor X; Target 2. Serine protease hepsin; Target 3. Tissue factor pathway inhibitor; Target 4. Vitamin K-dependent gamma-carboxylase; Target 5. Coagulation factor VII; Target 6. Tissue factor