Structure
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain.
Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neurotrophin TRKB receptor binding. An important paralog of this gene is NTF3.
Three dimensional structures for BDNF Gene
Function
Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. Diseases associated with BDNF include Wilms Tumor, Aniridia, Genitourinary Anomalies, And Impaired Intellectual Development Syndrome and Mood Disorder. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Downstream signaling of activated FGFR2.
BDNF is the important signaling molecule that activates signaling cascades downstream of NTRK2. During it development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. BDNF participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
[BDNF precursor form]: It is the important signaling molecule that activates signaling cascades downstream of NTRK2. It activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).
Pathways
There are 60 pathways. Here are some of them.
14-3-3 Induced Intracellular Signaling
Actin-Based Motility by Rho Family GTPases
Activation of cAMP-Dependent PKA
Activation of PKA through GPCR
Activation of PKC through GPCR
Akt Signaling
Antioxidant Action of Vitamin-C
Apoptotic Pathways in Synovial Fibroblasts
BDNF Pathway
Breast Cancer Regulation by Stathmin1
cAMP Pathway
CDK5 Pathway
Cellular Apoptosis Pathway
CREB Pathway
CRHR Pathway
DHA Signaling
eIF2 Pathway
eNOS Signaling
Epithelial Adherens Junctions
ERK Signaling
ERK5 Signaling
Estrogen Pathway
Glioma Invasiveness
GPCR Pathway
Drugs
About FGF2, there are 163 pipelines under study, 81 of which have been approved.
Citalopram is a selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression.
Venlafaxine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder.
Escitalopram is a selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Fluoxetine is a selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.
Metamfetamine is a sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Olanzapine is an antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
Dopamine is a catecholamine neurotransmitter used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output, and hypotension. Histamine is an ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
Ketamine is a rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant.
Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest.
Valproic acid is an anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Desipramine is a tricyclic antidepressant used in the treatment of depression.
