Brain-derived Neurotrophic Factor Human Recombinant produced in E.Coli is a homodimer, non-glycosylated, polypeptide chain containing 2 x 119 amino acids (and an N-terminal Met) and having a total molecular mass of 27kDa.
BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. BDNF is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the cns. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (ltp), long-term depression (ltd), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
>97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Sterile Filtered White lyophilized (freeze-dried) powder. The protein was lyophilized without any additives.
The ED50, as determined by the dose-dependent induction of C6 cells proliferation, is 1.3-2µg/ml.
It is recommended to reconstitute the lyophilized BDNF in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
BDNF is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the cns.
Examples of Clinical Use:
Regulator of synaptic transmission and plasticity at adult synapses in many regions of the cns.
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain.
Gene Ontology (GO) annotations related to this gene include signaling receptor binding and neurotrophin TRKB receptor binding. An important paralog of this gene is NTF3.
Three dimensional structures for BDNF Gene
Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. Diseases associated with BDNF include Wilms Tumor, Aniridia, Genitourinary Anomalies, And Impaired Intellectual Development Syndrome and Mood Disorder. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Downstream signaling of activated FGFR2.
BDNF is the important signaling molecule that activates signaling cascades downstream of NTRK2. During it development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. BDNF participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
[BDNF precursor form]: It is the important signaling molecule that activates signaling cascades downstream of NTRK2. It activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).
There are 60 pathways. Here are some of them.
14-3-3 Induced Intracellular Signaling Actin-Based Motility by Rho Family GTPases Activation of cAMP-Dependent PKA Activation of PKA through GPCR Activation of PKC through GPCR Akt Signaling Antioxidant Action of Vitamin-C Apoptotic Pathways in Synovial Fibroblasts BDNF Pathway Breast Cancer Regulation by Stathmin1 cAMP Pathway CDK5 Pathway Cellular Apoptosis Pathway CREB Pathway CRHR Pathway DHA Signaling eIF2 Pathway eNOS Signaling Epithelial Adherens Junctions ERK Signaling ERK5 Signaling Estrogen Pathway Glioma Invasiveness GPCR Pathway
About FGF2, there are 163 pipelines under study, 81 of which have been approved.
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