ANGPTL6 was originally named angiopoietin-related growth factor (AGF) having an N-terminal coiled-coil-like domain and a C-terminal fibrinogen-like domain, both of which are conserved in ANG. It is a circulating protein secreted by liver that induces angiogenesis by direct effect of epidermal ANGPTL6 on endothelial cells and proliferation of skin cells, and thereby promotes wound healing. It was concluded that ANGPTL6 is a hepatocyte-derived circulating factor that counteracts obesity and obesity-related insulin resistance, meaning that ANGPTL6 may be a novel biomarker for metabolic diseases. ANGPTL6 is a protein-coding gene which takes part is several processes. ANGPTL6 is involved in the wound healing process, promotes the chemotactic activity of endothelial cells and induce neovascularization. ANGPTL6 also counteracts high-fat diet-induced obesity and related insulin resistance through increased energy expenditure. Additionally ANGPTL6 promotes epidermal proliferation, remodeling and regeneration. Diseases linked with ANGPTL6 include enterobiasis, and gnathomiasis.
>90.0% as determined by SDS-PAGE.
White lyophilized (freeze-dried) powder. Filtered (0.4 µm) and lyophilized from a 0.5mg/ml solution containing 0.05M Acetate buffer pH 4.0.
ANGPTL6 is involved in the wound healing process, promotes the chemotactic activity of endothelial cells and induce neovascularization. ANGPTL6 also counteracts high-fat diet-induced obesity and related insulin resistance through increased energy expenditure. Additionally ANGPTL6 promotes epidermal proliferation, remodeling and regeneration.
Examples of Clinical Use:
Promoting wound healing and the chemotactic activity of endothelial cells, and inducing neovascularization.
ANGPTL6 is encoded by the human gene ANGPTL6, also known as ARP4. Its gene is located on human chromosome 19q13.1. The protein encoded by this gene is an angiopoietin-like adiponectin that plays multiple regulatory functions in the extracellular matrix. ANGPTL6 belongs to the angiopoietin like protein (ALPS) family without a tyrosine kinase domain. It is expressed in various tissues and organs, such as the liver, myocardium, kidneys, ovaries, bone marrow, etc. In the liver, ANGPTL6 is mainly localized in liver cells, hepatic stellate cells, and BALB/c mice.
The Function of ANGPTL6
ANGPTL6 is a secreted protein that has been shown to play an important role in many important physiological and pathological processes. ANGPTL6 affects insulin sensitivity and glucose metabolism through multiple pathways and can serve as a novel target for obesity and related diseases.
Some studies have shown that ANGPTL6 plays a role in inhibiting the oxidation process of fatty acids in the liver to maintain the accumulation of triacylglycerol lipids in the liver. In terms of lipid metabolism, the ANGPTL6 protein interacts with glutamine synthetase (GATM) in the liver, adipose tissue, and muscle, inhibiting the catalytic effect of GATM in acidic environments, inhibiting the synthesis of creatine, increasing the level of phosphocreatine in muscle, and thus promoting muscle metabolism.
In addition, ANGPTL6 can also regulate cell proliferation and differentiation during embryonic development and affect the process of embryonic development.
ANGPTL6 related signaling pathway
The main mechanism of action of ANGPTL6 involves lipid metabolism and inflammatory response processes. Research has shown that ANGPTL6 inhibits the oxidation process of fatty acids by inhibiting the activity of enzymes such as fatty acid oxidase CPT1, ACOX, and AOX. At the same time, ANGPTL6 can also serve as an activator of the JAK-STAT3 signaling pathway and exert certain anti-inflammatory effects in the body.
ANGPTL6 related diseases
Currently, many studies have shown that ANGPTL6 is involved in the occurrence and development of various diseases. For example, obesity, metabolic syndrome, type 2 diabetes, etc. are closely related to the change of the expression level of ANGPTL6. In addition, some studies have shown that ANGPTL6 is also involved in the occurrence, development, and metastasis of some tumors.
In obese and type 2 diabetes patients, the expression level of ANGPTL6 protein was significantly reduced, suggesting that ANGPTL6 played an important role in inhibiting fatty acid absorption and synthesis. During myocardial infarction, the level of serum ANGPTL6 increases, which may be related to angiogenesis, platelet aggregation and inflammatory reaction. The expression level of ANGPTL6 in the plasma of liver cancer patients decreased.
This finding suggests that ANGPTL6 may become a potential therapeutic target in clinical diagnosis and treatment. Therefore, further exploration of the physiological function of ANGPTL6 may have important significance in disease prevention and treatment.
The potential application of ANGPTL6 protein in medicine
Due to the important role that ANGPTL6 plays in metabolic pathways and inflammatory processes, it has great potential in controlling and preventing some related diseases. Some scientists even believe that by intervening in the function of ANGPTL6, new drugs that are effective for various diseases can be developed.
Research has shown that ANGPTL6 is involved in the metabolism of skeletal muscle and adipose tissue. Therefore, ANGPTL6 may be an important molecule in regulating muscle metabolism and metabolic diseases such as obesity. Meanwhile, some studies have also shown that overexpression of ANGPTL6 can inhibit the insulin signaling pathway and increase insulin resistance. According to this finding, ANGPTL6 may become a potential target for the treatment of diabetes.
List of ANGPTL6 related drugs under research
At present, drug that directly targets ANGPTL6 has not been developed. However, some studies suggest that certain compounds may indirectly interfere with the activity of ANGPTL6 to treat related diseases. For example, AMG-6, a compound currently under determination, is said to reduce the secretion and role of ANGPTL6, thereby improving the pathological process related to obesity and diabetes. Other novel drugs still under research and development may also become important representatives of ANGPTL6 in the field of medical applications, including anticancer drugs, anti-apoptotic drugs, and drugs that regulate insulin release.
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