Yellow Fever Vaccine

Specification

• Cat#: VAC-0339
• Product Name: Yellow Fever Vaccine
• Description: The Yellow Fever vaccine protects against Yellow Fever, a viral hemorrhagic disease caused by the transmission of a flavivirus through the bite of an infected mosquito. Symptoms of Yellow Fever can vary from asymptomatic to mild flu-like illness, and more severe symptoms such as shock, jaundice, internal bleeding, and organ failure. Interestingly, the name "Yellow Fever" comes from the characteristic yellowing of the skin and eyes due to jaundice when the virus attacks the liver. While supportive treatment is available for managing Yellow Fever, there are currently no antiviral medications specifically developed to treat it. Therefore, vaccination with the Yellow Fever vaccine is considered the most important and effective measure to protect against the disease. Protective immunity develops within 10 days after vaccination, with 90% of subjects in clinical trials seroconverting within 10 days and 100% within 14 days. The World Health Organization no longer recommends a 10-year booster dose following primary immunization, as a single dose is deemed sufficient to confer lifelong immunity against Yellow Fever. The disease is most commonly found in the southern hemisphere, particularly in tropical regions of Africa and Central/South America. The World Health Organization recommends routine vaccination in countries where Yellow Fever is endemic, and for travelers to these areas, as proof of vaccination is often required at border crossings to prevent the international spread of the disease. The Yellow Fever vaccine is administered subcutaneously for the active immunization and prophylaxis of Yellow Fever in pediatric patients 9 months of age and older. It is composed of two live, attenuated strains of the Yellow Fever virus, 17D-204 and 17DD, which have been shown to elicit an immune response identical to that induced by wild-type infection. Vaccination with the Yellow Fever vaccine is recommended for individuals living in or traveling to endemic areas and for laboratory personnel who handle virulent Yellow Fever virus or concentrated preparations of the vaccine virus.