Verpasep caltespen

Specification

• Cat#: THP-0189
• Product Name: Verpasep caltespen
• Description: The product is a recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7.
• Sequences: Not Available
• Molecular Weight: Not Available
• Cas No: 295371-00-5
• Formula: Not Available
• Endotoxin Level: <0.001 EU per 1 μg of the peptide by the LAL method

Pharmaceutical Information

• Pharmaceutical Application: HspE7
• Applications: Investigated for use/treatment in anal dysplasia, cervical dysplasia/cancer, genital warts, HIV infection, infectious and parasitic disease (unspecified), pediatric indications, warts, and viral infection.
• Examples of Clinical Use: Anal dysplasia, cervical dysplasia/cancer, genital warts, HIV infection, infectious and parasitic disease (unspecified), pediatric indications, warts, and viral infection.
• Pharmacodynamics: Not Available
• Mechanism of action: HspE7 works by efficiently delivering the E7 antigen to dendritic cells, which have a natural affinity for Hsp. Dendritic cells are known to be the most potent cells in the body for triggering immune responses. Coupling E7 to Hsp takes advantage of the Hsp receptors that dendritic cells express on their surface to introduce E7, as part of a larger fusion protein, into the dendritic cells.
• Affected organisms: Humans and other mammals
• Targets: Target 1. Keratin, type II cytoskeletal 7; Target 2. E3 ubiquitin-protein ligase UBR4