Vascular Endothelial Growth Factor (VEGF)

Specification

• Cat#: THP-0250
• Product Name: Vascular Endothelial Growth Factor (VEGF)
• Description: Recombinant Human VEGF is a 38.2 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
• Sequences: APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
• Species: Human
• Molecular Weight: 38.2 kDa
• Source: E. coli
• Introduction: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.
• Purity: ≥98% by SDS-PAGE gel and HPLC analyses.
• Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-8.0 ng/ml.

Pharmaceutical Information

• Applications: VEGF stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability.
• Examples of Clinical Use: Taking part in tumor metastasis and intra-ocular neovascular syndromes.
• Affected organisms: Humans