Urinary Trypsin Inhibitor (UTI)

Specification

• Cat#: THP-0218
• Product Name: Urinary Trypsin Inhibitor (UTI)
• Description: Recombinant Ulinastatin produced in Yeast is a single, glycosylated, polypeptide having 143 amino acids, molecular mass of 20 kDa and predicted pI of 4.5.
• Sequences: AVLPQEEEGS GGGQLVTEVT KKEDSCQLGY SAGPCMGMTS RYFYNGTSMACETFQYGGCM GNGNNFVTEK ECLQTCRTVA ACNLPIVRGP CRAFIQLWAFDAVKGKCVLF PYGGCQGNGNKFYSEKECRE YCGVPGDGDE ELL
• Species: Human
• Molecular Weight: 20 kDa
• Source: Yeast
• Introduction: Urinary-Trypsin Inhibitor is a glucoprotein proteinase inhibitor with a molecular weight of about 67,000 derived from human urine which inhibits the activity of trypsin, chymotrypsin, lactate, lipase, hyaluronidase and various pancreatic enzymes. UTI is effective for acute pancreatitis, chronic recurrent pancreatitis and hemorrhagic, traumatic and endotoxic shocks. UTI is has strong inhibition effect to various protease, sugar and fat hydrolase. UTI precursor is proteolytically processed into distinct functioning proteins. urinary trypsin inhibitor belongs to the superfamily of Kunitztype protease inhibitors and plays an important role in many physiological and pathological processes. UTI gene is located on chromosome 9 in a cluster of lipocalin genes. High levels of UTI secretion is an early marker of renal tubular involvement and has radical scavenging activity. Bikunin localizes cell membrane. Free uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma. UTI particularly interacts with ORF3 protein of hepatitis E virus and in charge for enhancing alpha microglobulin export from the hepatocyte.
• Purity: >98.0% as determined by:(a) Analysis by RP-HPLC.(b) Anion-exchange FPLC.
• Endotoxin: <1 EU per 1 μg of the peptide by the LAL method
• Biological Activity: Greater than 3000U/mg as measured by BAEE method.
• Application: UTI is effective for acute pancreatitis, chronic recurrent pancreatitis and hemorrhagic, traumatic and endotoxic shocks.

Pharmaceutical Information

• Pharmaceutical Application: Ulinastatin