Cat# : THP-0292
|THP-0292||Trafermin, Recombinant human basic fibroblast growth factor||June 05, 2023||1 vial||$3,998.00||
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|Product Name:||Trafermin, Recombinant human basic fibroblast growth factor|
|Description:||Trafermin, also known as recombinant human basic fibroblast growth factor (rhbFGF), is a recombinant form of human basic fibroblast growth factor (bFGF) which is marketed in Japan as a topical spray for the treatment of skin ulcers. It is also currently in preregistration for the treatment of periodontitis. As a recombinant form of bFGF, trafermin is a potent agonist of the FGFR1, FGFR2, FGFR3, and FGFR4. The drug has been marketed in Japan since June 2001.|
|Molecular Weight:||17.122 kDa|
|Purity:||>99% by SDS-Page and HPLC analysis|
|Endotoxin Level:||<0.001 EU per 1 μg of the peptide by the LAL method|
|Applications:||Investigated for use/treatment in coronary artery disease, peripheral vascular disease, periodontal disease, bone fractures, entero-related fistulae, and diabetic foot ulcers.|
|Examples of Clinical Use:||Periodontitis; Alveolar Bone Losses / Periodontal Attachment Loss / Periodontitis; Diabetic Foot Ulcer of Neuropathic Origin; Periodontitis; Tympanic Membrane Perforation|
|Mechanism of action:||Trafermin, or basic fibroblast growth factor 2 (bFGF) is a recombinant human growth factor used to stimulate angiogenesis and keratinization in wound healing. It stimulates migration of monocytes, neutrophils, macrophages, fibroblasts and also assists in creation of granulation tissue (the tissue that replaces fibrin clots in healing wounds).|
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