Talimogene laherparepvec; T-Vec

Specification

• Cat#: THP-0004
• Product Name: Talimogene laherparepvec; T-Vec
• Cas No: 1187560-31-1
• Description: The product is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. It specifically replicates within tumor cells and causes lysis.
• Sequences: Not Available
• Species: Human
• Molecular Weight: Not Available
• Formula: Not Available
• Biological Activity: 1000000 PFU/ml
• Application: This medication is a genetically modified oncolytic viral therapy indicated for the local treatment of unresectable, cutaneous, subcutaneous, and nodal lesions in patients with melanoma recurrent after initial surgery. Elsewhere, the EMA notes that the agent is indicated for the treatment of adults with unresectable melanoma that is regionally or distantly metastatic (Stage IIIB, IIIC, and IVM1a) with no bone, brain, lung, or other visceral diseases.

Pharmaceutical Information

• Pharmaceutical Application: Talimogene laherparepvec
• Targets: Target 1. Heparan sulfate; Target 2. DNA polymerase catalytic subunit; Target 3. DNA polymerase catalytic subunit