The product is a member of the keratase family which includes agents such as papain. It is able to dissolve the intercellular matrix which helps with desquamation. The product contains proteolytic enzymes derived from Bacillus subtilis and it is available as a cream-colored odorless powder. One gram of the product powder contains 250,000 casein units of proteolytic activity.
<0.001 EU per 1 μg of the peptide by the LAL method
82000 unit / g
The product was indicated, in the form of an ointment, as a biochemical debridement of second and third-degree burns, incisional traumatic and pyrogenic wounds and ulcers occurring due to peripheral vascular diseases.
Examples of Clinical Use:
Second and third-degree burns, incisional traumatic and pyrogenic wounds and ulcers occurring due to peripheral vascular diseases.
Reports indicated that the product exhibited a rapid and effective debridement when used for the treatment of burns, decubiti and traumatic wounds. In the case of peripheral vascular ulcerations, it did not respond in a predictable manner. When used, the product caused a rapid dissolution of the surface of the treated skin zone. However, a graftable wound bed as achieved no more rapidly than if saline soaks had been used since the enzyme appears to be ineffective in removing deep dermal elements and necrotic fat.
Mechanism of action:
Sutilain is a proteolytic enzyme that dissolves necrotic tissue and hyaluronidase.[T170]
Sutilain is a protease belonging to a group of granulocyte-producing enzymes. It is a protease with tissue-sealing activity and is composed of members of the trypsin family. Sutilain has the highest activity mainly under neutral conditions, and can play a role in protein degradation and digestion in the extracellular environment. Sutilain can degrade and break down a variety of proteins, including collagen, fibrin, blood clots, and cellulose. Therefore, it is widely used in the medical field. For example, during wound debridement and healing after trauma or surgery, Sutilain can help remove dead tissue and promote wound repair and healing. In addition, Sutilain can be used for biomedical applications in the preparation of tissue-engineered scaffolds, bone repair, and soft tissue repair materials. It has good biocompatibility and has high potential in tissue engineering. It is important to note that when treating with Sutilain, it should be used strictly in accordance with the doctor's guidance and dosage to avoid the risk of excessive digestion and adverse reactions.
2. Clinical application
Sutilain has a variety of clinical applications, including but not limited to the following: (1) Wound treatment: Sutilain is often used in wound debridement and healing after trauma or surgery. It can help remove necrotic tissue and promote wound repair and healing. (2) Burn treatment: Sutilain can be used for burn wound treatment to help remove eschar and necrotic tissue, and promote wound healing and skin regeneration. (3) Organ transplant surgery: Sutilain is used in organ transplant surgery to treat dead tissue in the transplanted tissue or organ, reduce postoperative complications, and promote healing. (4) Soft tissue repair: Sutilain is used in the preparation of soft tissue repair materials, which can accelerate the degradation of biological materials and the process of tissue repair. (5) Protein degradation and analysis: Sutilain can be used for protein degradation and analysis to help researchers understand the structure and function of proteins.
3. Mechanism of action
Sutilain (EC 184.108.40.206) is an endoprotease that can cleave a variety of proteins at peptide bonds. The mechanism of action is mainly related to the catalytic activity and subcellular localization of Sutilain. The catalytic activity of Sutilain depends on the physical and chemical properties of the protein substrate. The substrate complex is a stable substrate enzyme complex. The amino acid side chain in the substrate interacts with the active center of Sutilain to form hydrogen bonds, and the activation state of water molecules in the active center increases. The water molecules then undergo a catalytic nucleotide attack and trypsin active hydrolysis of the digestive substrate. In addition, the mechanism of action of Sutilain at the subcellular level is related to its intracellular coupling. Sutilain is mainly located in the cytoplasmic and cytoplasmic matrix and plays a role in the process of energy metabolism, protein synthesis, and repair by coupling with other enzymatic proteins. In clinical applications such as wound healing and wound treatment, Sutilain mainly breaks down dead and hard tissues through its proteolytic action to promote repair and healing. In addition, for protein degradation and analysis, Sutilain can also help researchers in related fields by selective cutting for specific substrate sequences.
4. Pros and cons of the application
Advantages: (1) Removal of necrotic tissue: Sutilain has strong proteolytic ability, which can effectively remove necrotic tissue from wounds or wounds, and promote wound healing and tissue repair. (2) Promote wound healing: Sutilain can speed up the wound healing process, reduce healing time, and help improve the quality of life of patients. (3) Wide application: Sutilain is widely used in the medical field, covering wound treatment after trauma surgery, burn wound treatment, organ transplantation, and other aspects. (4) Good biocompatibility: Sutilain has good biocompatibility, no obvious adverse reactions to human tissues, and high safety. Disadvantages: (1) Risk of side effects: Side effects may occur when Sutilain is used for treatment, such as allergic reactions, pain, or swelling. (2) Limitations of use: Sutilain may not be suitable in some cases, such as low sensitivity to specific substrates, patient conjunctivitis, or inappropriate use. (3) Need professional guidance: The use of Sutilain should be guided and supervised by a professional doctor or medical personnel to ensure the correct dosage and avoid potential risks. (4) Cost consideration: Sutilain may have a high cost, which may require patients to bear a certain cost burden.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products
without prior written approval from Creative BioMart.
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