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Recombinant Norovirus Group-1 Capsid P-Domain Antigen, His-tagged

Cat# : VAC-0283

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
VAC-0283 Recombinant Norovirus Group-1 Capsid P-Domain Antigen, His-tagged May 18, 2024 0.5ml $998.00
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Cat#:  VAC-0283
Product Name:  Recombinant Norovirus Group-1 Capsid P-Domain Antigen, His-tagged
Description:  The Recombinant Norovirus Group-1 Capsid P-Domain, E. coli derived, Norwalk strain contains a.a. from 225-520 having a Mw of 30 kDa. The protein is fused to a 6 × His tag at N-terminal and purified by chromatography techniques.P-domain (225-520 a.a.) forms P1- P2-P1 structure. P-domain has a receptor binding region to recognize human histo-blood group antigens (HBGAs). P-domain expressed in bacteria can spontaneously form a P dime and a P particle aggregated by 12 P dimmers. P-particle displays an enhanced binding activity to HBGAs higher than virus-like particle (VLP) formed by the full length capsid.
Species:  Norovirus
Molecular Weight:  30 kDa
Source:  Escherichia Coli.
Introduction:  Human norovirus is classified into two groups, group 1& group 2. Norwalk virus is the species which belongs to group 1 and was discovered in 1968 at Ohio. Norovirus is a familiar virus which causes human gastroenteritis with the following symptoms vomiting, diarrhea and sickness. CDC report revealed that there are 19-21 million Americans infected by Nororvirus annually with 800 deaths, 1 in 15 people with infection. Around the world, this virus affects about 267 million people and causes over 200,000 deaths each year; these losses are mostly in less developed countries and in the very young, elderly and immuno-suppressed population, though, most cases are self-limited with a full recovery within just a few days. Norovirus is extremely contagious and can spread from human to human through infected food, water or contaminated surfaces. The outbreaks usually occur from November-April, while the peak is in January. Norovirus is a positive sense RNA virus with 7.5 kb nucleotides, encoding a major structural protein VP1 with 50-55 kDa. The full length ofVP1 capsid comprises the internal N-terminal, Hinge, shell (S) and protruding (P) domains. P domain from 225 to 520 forms P1- P2-P1 structure. Moreover, P domain has a receptor binding region which recognizes human histo-blood group antigens (HBGAs). P domain expressed in bacteria can spontaneously form a P dime as well as a P particle aggregated by 12 P dimmers. P particle displays an increased binding activity to HBGAs higher than virus-like particle (VLP) formed by the full-length capsid. For norovirus vaccine development, we consider P domain as a good candidate.
Purity:  Protein is >95% pure as determined by 12% PAGE (coomassie staining).
Formulation:  Phosphate buffer and 10 mM K2CO3.
Stability:  The Recombinant Norovirus Group-1 P-Domain although stable at 4°C for 1 week, should be stored below -18°C.Please prevent freeze thaw cycles.
Physical Appearance:  Sterile Filtered clear solution.
Usage:  All the products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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