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Recombinant Human ACE2 Protein, His-tagged

Cat# : ACE2-360

Product Datasheets COA :
Cat#:  ACE2-360
Product Name:  Recombinant Human ACE2 Protein, His-tagged
Description:  The HEK293 derived ACE2 Human recombinant protein contains the amino acids 18-740 fused to His tag at N-terminal. ACE2 Protein binds to SARS Coronavirus-2 [CoV-2019] Spike receptor binding domain.
Species:  Human
Source:  HEK293 Cells
Introduction:  ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries , lungs, heart & kidney. ACE2 an entry receptor of SARS coronaviruses as well as SARS-CoV-2,.The coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on the external envelope of the virion that takes part in a critical part in viral infection by identifying host cell receptors and facilitating fusion of the viral and cellular membranes. 2 main domains in coronavirus S1 have been recognized, the N-terminal domain and C-terminal domain. One or the other and/or both S1 domains function as a receptor-binding domain. SARS-CoV + MERS-CoV equally use C-domain to attach their receptors.ACE2 is a type I transmembrane antigen with an extracellular N-terminal domain having the catalytic site and an intracellular C-terminal tail. ACE2 obtains a signal peptide, a transmembrane domain, and a single metalloproteinase active site containing an HEXXH zinc-binding domain. ACE-2 plays a role as a mono-carboxypeptidase which degrades Ang I to produce the nonapeptide Ang 1-9 and Ang II to create the heptapeptide Ang 1-7.
Purity:  Protein is >95% pure as determined SDS-PAGE.
Formulation:  ACE2 Human protein solution is supplied in 50mM Tris-HCl, pH7.5, and 150mM NaCl and glycerol.
Stability:  ACE-2 Human RecombinantProtein is shipped on ice packs. Upon arrival, Store at -20°C.
Physical Appearance:  Sterile Filtered clear solution.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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