Recombinant HTLV-1 gp46 mosaic Antigen, His-tagged

Specification

• Cat#: HTL-251
• Product Name: Recombinant HTLV-1 gp46 mosaic Antigen, His-tagged
• Description: The E. coli derived recombinant mosaic protein contains the gp46 immunodominant region, 21-313 amino acids; Mw on SDA-PAGE is 34.2 kDa and fuse to 6 histidines at C-terminus.
• Species: HTLV-1
• Molecular Weight: 34.2 kDa
• Introduction: Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
• Purity: Protein is >90% pure as determined by SDS-PAGE.
• Stability: HTLV-1 gp46 although stable at 4°C for 1 week, should be stored below -18°C.Please prevent freeze thaw cycles.