Recombinant HTLV-1 gp21 Antigen, GST-tagged

Specification

• Cat#: HTL-250
• Product Name: Recombinant HTLV-1 gp21 Antigen, GST-tagged
• Description: The E. coli derived recombinant protein contains the gp21 immunodominant region, 351-404 amino acids, the MW is 21 kDa. Fused with a GST tag at N-Terminus.
• Species: HTLV-1
• Molecular Weight: 21 kDa
• Introduction: Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
• Purity: HTLV-1 gp21 is >95% pure as determined by 10% SDS-PAGE (coomassie staining) and HPLC-C4.
• Formulation: 60mM NaCl, 50mM Tris-HCl, pH-8.0, 0.25% Sarkosil, 50% Glycerol and 10mM Glutathione.
• Stability: HTLV-1 gp21 although stable at 4°C for 1 week, should be stored below -18°C.Please prevent freeze thaw cycles.

Pharmaceutical Information

• Applications: HTLV-1 gp21 can be used as an antigen in ELISA and Western Blots. Excellent reagent for correct detection of HTLV infections, with minimal specificity problems.