Cat# : VAC-0218
Catalog# | Product Name | Availability | Size | Price | Qty |
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VAC-0218 | Recombinant HIV-1 nef Clade B Antigen | October 10, 2024 | 0.5ml | $1,998.00 |
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Cat#: | VAC-0218 |
Product Name: | Recombinant HIV-1 nef Clade B Antigen |
Description: | The E. coli derived 27 kDa recombinant HIV-1 Nef Clade-B protein is a single non-glycosylated polypeptide chain. |
Species: | HIV-1 |
Molecular Weight: | 27 kDa |
Source: | Escherichia Coli. |
Introduction: | HIV-1 Nef is a 27 kDa protein highly produced after a very short time after virus infection. HIV-1 Nef is an essential factor for efficient viral replication and phatogenesis.HIV-1 Nef facilitates virus replication and improves virions infectivity. HIV-1 Nef exerts pleiotropic effect. HIV-1 Nef down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK thereby inducing LCK-CD4 dissociation and by increasing clathrindependent endocytosis of this antigen to target it to lysosomial degradation. HIV-1 Nef guards the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. HIV-1 Nef protein bypasses host Tcell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. |
Purity: | Greater than 90.0% as determined by HPLC analysis and SDS-PAGE. |
Stability: | Lyophilized HIV-1 nef although stable at room temperature for 1 week, should be stored desiccated below -18°C. Upon reconstitution HIV-1 nef should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
Usage: | All the products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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