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Recombinant HIV-1 nef Clade B Antigen

Cat# : VAC-0218

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
VAC-0218 Recombinant HIV-1 nef Clade B Antigen September 28, 2023 0.5ml $1,998.00
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Cat#:  VAC-0218
Product Name:  Recombinant HIV-1 nef Clade B Antigen
Description:  The E. coli derived 27 kDa recombinant HIV-1 Nef Clade-B protein is a single non-glycosylated polypeptide chain.
Species:  HIV-1
Molecular Weight:  27 kDa
Source:  Escherichia Coli.
Introduction:  HIV-1 Nef is a 27 kDa protein highly produced after a very short time after virus infection. HIV-1 Nef is an essential factor for efficient viral replication and phatogenesis.HIV-1 Nef facilitates virus replication and improves virions infectivity. HIV-1 Nef exerts pleiotropic effect. HIV-1 Nef down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK thereby inducing LCK-CD4 dissociation and by increasing clathrindependent endocytosis of this antigen to target it to lysosomial degradation. HIV-1 Nef guards the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. HIV-1 Nef protein bypasses host Tcell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation.
Purity:  Greater than 90.0% as determined by HPLC analysis and SDS-PAGE.
Formulation:  Lyophilized with 1% glycerol.
Stability:  Lyophilized HIV-1 nef although stable at room temperature for 1 week, should be stored desiccated below -18°C. Upon reconstitution HIV-1 nef should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Physical Appearance:  Sterile Filtered and lyophilized, though might appear as a solution as a result of the glycerol content.
Usage:  All the products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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