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Recombinant HIV-1 Clade-B TAT Antigen

Cat# : VAC-0209

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
VAC-0209 Recombinant HIV-1 Clade-B TAT Antigen June 16, 2024 0.5ml $1,998.00
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Cat#:  VAC-0209
Product Name:  Recombinant HIV-1 Clade-B TAT Antigen
Description:  HIV-1 TAT Recombinant-produced in E. coli is a single, non-glycosylated, polypeptide chain containing 86 amino acids encoded by two exons and having a molecular mass of 14 kDa.
Species:  HIV-1
Molecular Weight:  14 kDa
Source:  Escherichia Coli.
Introduction:  Human immunodeficiency virus type-1 (HIV-1) regulatory Tat protein plays an essential role in viral replication (Jones KA, 1994) and infectivity (Arya SK, 1985; Fisher AG, 1986). In addition, during acute infection, Tat is released extracellularly by infected cells (Chang HC, 1997; Ensoli B, 1990) and is taken up by neighboring cells where it transactivates viral replication (Ensoli B, 1993) and increases virus infectivity.HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Tat can also disturb cellular metabolism by inhibiting proliferation of antigen-specific T lymphocytes and by inducing cellular apoptosis. Tat-induced apoptosis of T-cells is attributed, in part, to the distortion of microtubules polymerization. LIS1 is a microtubule-associated protein that facilitates microtubule polymerization.
Purity:  Greater than 90.0% as determined by SDS-PAGE.
Formulation:  Lyophilized with 0.1% glycerol.
Stability:  Lyophilized HIV-1 TAT although stable at room temperature for 1 week, should be stored desiccated below -18°C. Upon reconstitution HIV-1 TAT should be stored at 4°C between 2-7 days and for future use below -18°C.For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Physical Appearance:  Sterile Filtered and lyophilized, though might appear as a solution as a result of the glycerol content.
Usage:  All the products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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