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Recombinant HERV-K truncated protein, His-tagged

Cat# : SARS-402

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
SARS-402 Recombinant HERV-K truncated protein, His-tagged April 20, 2024 1 vial $998.00
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Cat#:  SARS-402
Product Name:  Recombinant HERV-K truncated protein, His-tagged
Description:  The E. coli derived HERV-K recombinant truncated protein is fused to a Six histidine tag at C-terminus and has a MW of 51.5 kDa (pI 9.06).
Molecular Weight:  51.5 kDa
Source:  Escherichia Coli.
Introduction:  HERVK is related with several tumors such as passenger virus, and anti-Retroviral therapy against amyotrophic lateral sclerosis/ALS has exhibited to decrease the symptoms of amyotrophic lateral sclerosis/ALS. High counts of viral sequences exist in the human genome but stay silent. Though, in pathological conditions, these viruses are produced. Human Endogenous Retrovirus-K, is produced in neurons of a subpopulation of patients with amyotrophic lateral sclerosis/ALS, a progressive neurodegenerative disease. The envelope protein of this HERV results in degeneration of neurons, and transgenic animals producing this protein advance an ALS-like syndrome triggered by nucleolar dysfunction in motor neurons. Reactivation of the HERVK is controlled by the transcription factor TDP-43. Therefore, therapeutic tactics against this virus alter the course of the disease.
Purity:  Protein is >90% pure as determined by SDS PAGE.
Formulation:  10mM Tris-HCl, pH 7.2, 8M urea and 2mM EDTA.
Stability:  HERV-K although stable at 4°C for 1 week, should be stored below -18°C.Please prevent freeze thaw cycles.
Physical Appearance:  Sterile Filtered clear solution.
Usage:  All the products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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