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Recombinant Helicobacter pylori NAP Antigen, His-tagged

Cat# : VAC-0298

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
VAC-0298 Recombinant Helicobacter pylori NAP Antigen, His-tagged June 16, 2024 0.5ml $1,998.00
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Cat#:  VAC-0298
Product Name:  Recombinant Helicobacter pylori NAP Antigen, His-tagged
Description:  HP-NAP Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain (Met1-Ala144) containing 154 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 18.2 kDa.
Species:  H. pylori
Molecular Weight:  18.2 kDa
Source:  Escherichia Coli.
Introduction:  HP-NAP protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, thus preventing hydroxyl radical production by the Fenton reaction. HP-NAP is necessary for the survival in the presence of oxidative stress. Dps is also a virulence factor which activates neutrophils, mast cells and monocytes. HP-NAP binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. HP-NAP might play a part in the accumulation of neutrophils and monocytes at the site of infection. HP-NAP induces superoxide anion generation, adhesion and chemotaxis of neutrophils, via a pertussis toxin-sensitive pathway involving MAP kinases.
Purity:  Greater than 95.0% as determined by SDS-PAGE.
Formulation:  HP-NAP was filtered (0.4 µm) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5.
Stability:  Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Physical Appearance:  Filtered White lyophilized (freeze-dried) powder.
Usage:  All the products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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