Recombinant HBV core delta Antigen

Specification

• Cat#: H1V1-307
• Product Name: Recombinant HBV core delta Antigen
• Description: The E. coli derived 14 kDa recombinant protein contains the HBV core delta ayw immunodominant region amino acids 1-144.
• Species: HBV
• Molecular Weight: 14 kDa
• Introduction: Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.
• Purity: HBV Core Delta protein is >95% pure as determined bySDS-PAGE (coomassie staining).
• Formulation: 7.5mM Phosphate buffer pH-7.2, 75mM NaCl, & 50% glycerol.
• Stability: HBV Core Delta protein although stable at 4°C for 1 week, should be stored below -18°C.Please prevent freeze thaw cycles.
• Usage: All the products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Pharmaceutical Information

• Applications: HBV Core Delta antigen is suitable for ELISA and Western blots, excellent antigen for detection of HBV with minimal specificity problems.