Rabbit anti-thymocyte globulin

Specification

• Cat#: FMD-458
• Product Name: Rabbit anti-thymocyte globulin
• Description: Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
• Species: Rabbit
• Endotoxin Level: <0.001 EU per 1 μg of the peptide by the LAL method

Pharmaceutical Information

• Applications: For prevention of renal transplant rejection
• Examples of Clinical Use: Acute kidney transplant rejection, aplastic anaemia
• Pharmacodynamics: Antithymocyte Globulin (ATG) is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation. ATG reduces the host immune response against tissue transplants or organ allografts.
• Mechanism of action: Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.
• Affected organisms: Humans and other mammals
• Targets: 1. T-cell surface glycoprotein CD1a; 2. Major histocompatibility complex class I-related gene protein; 3. Integrin alpha-L; 4. T-lymphocyte activation antigen CD86; 5. Low affinity immunoglobulin gamma Fc region receptor II-b; 6. T-cell surface glycoprotein CD4; 7. Integrin beta-1; 8. Integrin alpha-V; 9. Integrin beta-3