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Platelet-Derived Growth Factor-AB (PDGF-AB)

Cat# : THP-0225

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
THP-0225 Platelet-Derived Growth Factor-AB (PDGF-AB) March 01, 2024 1 vial $3,998.00
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Cat#:  THP-0225
Product Name:  Platelet-Derived Growth Factor-AB (PDGF-AB)
Description:  PDGF-AB isomer is found to be associated with angiogenesis and proliferation. Potency: 10-100 ng/mL ED50/EC50.
Species:  Human
Molecular Weight:  27-31 kDa
Source:  E. coli
Introduction:  Platelet-Derived Growth Factor (PDGF) is a cationic polypeptide and a constituent of α-granules. PDGF is composed of chain A and B linked together by a disulphide bridge. PDGF heterodimers occurs as PDGF-AB and homodimers exists as FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD). The PDGFB gene is localized to pericytes in the brain and is mapped to human chromosome 7p22.3. Cellular actions of platelet-derived growth factor (PDGF) include chemoattraction and activation of neutrophils, monocytes, and fibroblasts. PDGF appears to play a crucial role in the cellular response to tissue injury and is critically involved in the pathological progression of atherosclerosis. PDGF stimulates fibroblast proliferation and extracellular matrix production in order to facilitate tissue repair.
Purity:  ≥97% (SDS-PAGE and N-terminal analysis)
Formulation:  Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid.
Biological Activity:  The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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