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Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF)

Cat# : THP-0223

Product Datasheets COA :
Catalog# Product Name Availability Size Price Qty
THP-0223 Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF) February 29, 2024 1 vial $3,998.00
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Cat#:  THP-0223
Product Name:  Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF)
Description:  Platelet-derived endothelial cell growth factor is a 45 kDa endothelial cell mitogen of pI 4.0-4.8 originally purified from human platelets. PD-ECGF is chemotactic for bovine aortic endothelial cells, however it does not induce smooth muscle cell migration. Potency: 5-30 ng/mL EC50
Species:  Human
Molecular Weight:  49 kDa
Source:  Baculovirus infected Sf21 cells
Introduction:  Platelet-Derived Endothelial Cell Growth Factor (PD-ECGF) is an endothelial cell mitogen which was originally purified from human platelets. In contrast with the endothelial mitogens of the fibroblast growth factor (FGF) family, PD-ECGF is an endothelial cell growth factor initially purified from human platelets, which does not bind to heparin and does not stimulate the proliferation of fibroblasts. This is in contrast with the effect of PDGF, which stimulates the growth of human foreskin fibroblasts, but is inactive on endothelial cells. PD-ECGF will stimulate endothelial cells in vitro and in vivo. PD-ECGF is chemotactic for bovine aortic endothelial cells. PD-ECGF does not induce smooth muscle cell migration. PD-ECGF is involved in angiogenesis and has potent angiogenic activity both in the developing vascular system of the chick chorioallantoic membrane and in vascularization of tumors in nude mice. PD-ECGF has a pI of 4.0-4.8 and a molecular weight of 49 kDa.
Purity:  ≥97% (SDS-PAGE)
Formulation:  lyophilized powder
Biological Activity:  The proliferative activity of human PD-ECGF is measured in culture by using human umbilical vein endothelial cells.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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