Bromelain is a category of protein-digesting enzymes that are obtained from the fruit or stem of pineapples. Although both fruit bromelain are prepared differently and contain different enzymatic compositions. Bromelain is consequently a composite mixture of several different endopeptidases that can facilitate many different reactions with many different substrates.
<0.001 EU per 1 μg of the peptide by the LAL method
The primary medical purpose for which the product is currently indicated for is the removal of eschar in adults with deep partial- and full-thickness thermal burns. Besides this official indication, however, it is also believed that SB may be used as a treatment for several other purposes as well, including cardiovascular health, osteoarthritis, autoimmunity, blood clotting, diarrhea, cancer, surgery, and debridement - although the specific mechanisms of action for these indications remain to be elucidated.
Examples of Clinical Use:
Eschar with deep partial- and full-thickness thermal burns
The product is ultimately a mixture of various different thiol endopeptidases that are capable of catalyzing a range of reactions on a number of different substrates, which is perhaps why the product can evidently be used as some manner of treatment in a range of therapeutic contexts. This notion is facilitated by the fact that various topical and oral administration preparations exist as well, further diversifying the ways in which the medication can be used. Perhaps the most important aspect of the product, however, is its ability to undergo intestinal absorption undegraded in a functionally intact form, ultimately preserving its proteolytic actions in the plasma. This kind of pharmacodynamic characteristic is another element that perhaps allows the product to remain active within the body and elicit a number of actions at several major body systems.
Mechanism of action:
Stem bromelain is ultimately a mixture of a number of thiol endopeptidases and other elements including phosphatases, glucosidase, peroxidases, cellulases, glycoproteins, carbohydrates, and various protease inhibitors. The many different substrates and reactions that these varied enzymes can catalyze results in a number of different and possible mechanisms of action.
Pineapple stem bromelain (Pineapple stem bromelain) is a protease isolated from pineapple stem juice, belonging to the Bromeliaceae family, with many clinical and industrial applications, and is widely used in food, medicine, and daily chemical industry. Pineapple stem bromelain is a kind of endonaseptic enzyme, which is often used to decompose protein and promote the digestion and absorption of protein. It has the ability to efficiently degrade protein and can hydrolyze meat, dairy, fish, and plant proteins that are difficult to handle compared with other enzymes so that they can be decomposed into peptides and amino acids that are easy to digest and absorb. Pineapple stem bromelain also has anti-inflammatory, antiplatelet, and anticoagulant effects, and is also important in the fields of tumor treatment and wound treatment. Therefore, Pineapple stem bromelain is a very valuable natural protease and has its unique application value in different fields.
2. Mechanism of action
The mechanism of action of Pineapple stem bromelain in clinical application mainly involves the following aspects: (1) Proteolytic enzyme activity: Pineapple stem bromelain has strong proteolytic enzyme activity, which can accelerate the decomposition and digestion of protein. It can cut the amide bond in the protein molecule and decompose the protein into smaller peptide chains or amino acids, thus increasing the availability and digestibility of protein. (2) Anti-inflammatory effect: Pineapple stem bromelain has a potential anti-inflammatory effect, which can reduce inflammatory response by inhibiting the activation of inflammatory cells and the release of inflammatory mediators, which helps to alleviate inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. (3) Anti-platelet and anticoagulant effect: Pineapple stem bromelain can inhibit platelet aggregation and thrombosis, and reduce the activity of clotting factors, which is of great significance for the prevention of cardiovascular diseases and thrombosis. (4) Immune regulation: Studies have shown that Pineapple stem bromelain has the ability to regulate the immune system, promote the proliferation and activation of immune cells, and enhance immune function, which has potential benefits for improving immune-related diseases and enhancing the body's resistance. It should be pointed out that there may be other unknown molecular mechanisms in the mechanism of action of Pineapple stem bromelain, and its specific effect may depend on factors such as dose, use mode, and application environment. Therefore, in clinical application, it should be used rationally according to the specific situation, and monitored and adjusted under the guidance of doctors.
3. Clinical application
Pineapple stem bromelain has the following aspects in clinical application: (1) Digestive aid: Pineapple stem bromelain has strong proteolytic enzyme activity and is widely used in digestive aid therapy. It can cut the amide bond in the protein molecule and decompose the protein into smaller peptide chains or amino acids, thereby increasing the availability and digestibility of the protein. (2) Anti-inflammatory and pain relief: Pineapple stem bromelain has anti-inflammatory effects, which can reduce inflammation by inhibiting the activation of inflammatory cells and the release of inflammatory mediators. Therefore, it can be used to treat inflammatory diseases and relieve joint pain. (3) Improve immune function: Pineapple stem bromelain can regulate the function of the immune system and enhance the activity of immune cells. Therefore, it can be used to improve immune-related diseases. (4) Antithrombotic: Pineapple stem bromelain can inhibit platelet aggregation and thrombosis, and reduce the activity of clotting factors. It can be used to prevent thrombotic diseases. (5) Wound healing: Pineapple stem bromelain also stimulates wound healing and can be used to accelerate wound healing and reduce scar formation. In addition to the above aspects, there are also related clinical application studies in the fields of tumor therapy and cardiovascular diseases, so it can be seen that Pineapple stem bromelain has a very wide application prospect.
4. Pipeline is under investigation
Pineapple stem bromelain has some new advances and potential applications in clinical research. Here are some related research directions: (1) Anti-tumor studies: Previous studies have shown that Pineapple stem bromelain has anti-tumor activity, which can inhibit the proliferation and invasion of tumor cells and induce tumor cell apoptosis. Clinical trials are currently underway to investigate its potential in cancer treatment. (2) Treatment of inflammatory diseases: The anti-inflammatory effect of Pineapple stem bromelain has been extensively studied, and it has potential application in the treatment of inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. More in-depth studies are being conducted to understand the mechanism and determine its clinical effects. (3) Wound and wound Treatment: Pineapple stem bromelain has been found to promote wound healing and reduce scar formation. Research is ongoing to further understand its therapeutic potential for wounds and wounds. (4) Immune regulation: The immunomodulatory effects of Pineapple stem bromelain have also received attention, and research is being conducted to explore its potential application in the treatment of immune-related diseases. It should be noted that although Pineapple stem bromelain has shown many potential applications in clinical studies, more research is needed to verify its clinical effect, dose, and safety.
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