Native Porcine Pancreas Colipase

Specification

• Cat#: THP-128
• Product Name: Native Porcine Pancreas Colipase
• Description: Pancreatic lipase when prepared essentially free of co-lipase is strongly inhibited by conjugated bile salts at or above their critical micell concentration. Addition of co-lipase restores activity to the bile-salt-inhibited lipase and gelfilteration experiments indicate that co-lipase in bile salt solution makes a dimer which forms a 1:1 complex with lipase (Morgan, R.G., and N.E. Hoffman, Biochim Biophys Acta, 248, 143-148, 1971). Lipase and co-lipase interact as a stoichiometrical relationship and classified co-lipase interact as a co-enzyme for lipase. The co-lipase is a single chain polypeptide with a molecular weight approximately 11,000 with 5 disulfide bridges and isoelectric point 5.0. (Mayie, M.E., et al, Biochim Biophys Acta, 271, 400-412, 1971).
• Species: Porcine Pancreas
• Molecular Weight: molecular weight approximately 11,000
• Source: Porcine Pancreas
• Stability: Store at -20° C (-4° F)
• Physical Appearance: Freeze-dried powder