Native Human Spleen Cathepsins D

Specification

• Cat#: THP-126
• Product Name: Native Human Spleen Cathepsins D
• Description: Cathepsins are a group of intracellular proteolytic enzymes located within the lysosomes. On the basis of the specificity towards their substrates, the cathepsins have been assigned the names: Cathepsins A, B, C, D, E, G and L.Cathepsin D (EC 3.4.23.5) has been found to be widely distributed in various tissues but spleen is a rich source of this enzyme. Cathepsins A and D work synergistically to hydrolyze protein substrates. The rabbit liver Cathepsin D has a molecular weight of approximately 58,000 and it can be stored at 4° at pH 3-4 or at pH 8 for days without loss of significant amount of its activity (Press, E.M., Porter, R.R. and J. Cebra, Biochem J., 74, 501, 1960). Cathepsin D acts as a true proteinase on substrates such as denatured hemoglobin at the pH range of 2.8-3.0. In this respect it behaves enzymatically similar to pepsin.
• Species: Human Spleen
• Molecular Weight: The rabbit liver Cathepsin D has a molecular weight of approximately 58,000 .
• Source: Human Spleen
• Stability: Store at -20° C (-4° F)
• Physical Appearance: Freeze-dried powder