Interleukin 7 (IL-7)

Specification

• Cat#: THP-0268
• Product Name: Interleukin 7 (IL-7)
• Description: Interleukin 7 (IL-7) protein is produced by E. coli expression system.
• Sequences: MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH
• Species: Human
• Molecular Weight: 17 kDa
• Source: E. coli
• Introduction: IL7, also known as interleukin 7, is a hematopoietic growth factor which belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes.
• Purity: > 95 % SDS-PAGE. This protein is purified by proprietary chromatographic techniques. Purity is greater than 98.0% as determined by RP-HPLC and SDS-PAGE.
• Formulation: Lyophilised
• Biological Activity: Biological Activity: The ED50 as determined by the dose-dependant stimulation of murine IXN/2B cells is <0.5ng/ml, corresponding to a Specific Activity of 2 x 106 IU/mg.
• Reconstitution: Reconstitute in sterile 18MOhm-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Pharmaceutical Information

• Applications: IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
• Examples of Clinical Use: Stimulating the proliferation of lymphoid progenitors.
• Affected organisms: Humans