Highly purified sheep/ovine hyaluronidase

Specification Drug Information Related Products

Cat#:	THP-0122
Product Name:	Highly purified sheep/ovine hyaluronidase
Description:	Native Highly purified sheep hyaluronidase.
Sequences:	MWTGLGPAVTLALVLVVAWATELKPTAPPIFTGRPFVVAWDVPTQDCGPRHKMPLDPKDMKAFDVQASPNEGFVNQNITIFYRDRLGMYPHFNSVGGSVHGGVPQNGSLWVHLEMLKGHVEHYIRTQEPAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASHHPDWPPERIVKEAQYEFEFAARQFMLETLRFVKAFRPRHLWGFYLFPDCYNHDYVQNWETYTGRCPDVEVSRNDQLSWLWAESTALFPSVYLEETLASSTHGRNFVSFRVQEALRVADVHHANHALPVYVFTRPTYSRGLTGLSEMDLISTIGESAALGAAGVILWGDAGFTTSNETCRRLKDYLTRSLVPYVVNVSWAAQYCSWAQCHGHGRCVRRDPNAHTFLHLSASSFRLVPSHAPDEPRLRPEGELSWADRNHLQTHFRCQCYLGWGGEQCQWDRRRAAGGASGAWAGFHLTGLLAVAVLAFTWTS
Species:	Sheep
Molecular Weight:	53870.9 Da
Cas No:	488712-31-8
Formula:	C2455H3775N617O704S21
Endotoxin Level:	<0.001 EU per 1 μg of the protein by the LAL method
Biological Activity:	200U/ml or 6200U/5ml

Drug Name:	Hyaluronidase (ovine)
Applications:	For increase of absorption and distribution of other injected drugs and for rehydration.
Examples of Clinical Use:	Absorption and distribution of other injected drugs
Pharmacodynamics:	The product hydrolyzes hyaluronic acid and increase diffusion of injected drugs, thus facilitating their absorption. The product is used for enhancing absorption and distribution of other injected drugs.
Mechanism of action:	Hyaluronidase is a spreading or diffusing substance. It increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.
Affected organisms:	Humans and other mammals
Targets:	Target 1. Hyaluronan; Target 2. Transforming growth factor beta-1; Enzyme 1. Serum albumin

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