Gastric intrinsic factor, GIF

Specification

• Cat#: THP-0072
• Product Name: Gastric intrinsic factor, GIF
• Description: The product is a glycoprotein produced by the parietal cells of the stomach that is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. When vitamin B12 is provided in combination with intrinsic factor, intrinsic factor reduces protease degradation and increases absorption of Vitamin B12.
• Sequences: Not Available
• Species: Human
• Molecular Weight: Not Available
• Cas No: Not Available
• Formula: Not Available
• Endotoxin Level: <0.001 EU per 1 μg of the protein by the LAL method

Pharmaceutical Information

• Pharmaceutical Application: Gastric intrinsic factor
• Applications: The product is not currently available in any FDA or Health Canada approved products. However, it is currently in combination with cyanocobalamin (synthetic Vitamin B12), ferrous fumarate, and ascorbic acid for the treatment of anemias responsive to oral iron therapy.
• Examples of Clinical Use: Anemias
• Pharmacodynamics: Not Available
• Mechanism of action: Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach that is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. When vitamin B12 is provided in combination with intrinsic factor, intrinsic factor reduces protease degradation and increases absorption of Vitamin B12.
• Affected organisms: Not Available