Factor XIII (human)

Specification

• Cat#: THP-0069
• Product Name: Factor XIII (human)
• Cas No: 9013-56-3
• Description: The product is a heat-treated, lyophilized concentrate of coagulation factor XIII, an endogenous enzyme responsible for the crosslinking of fibrin and an essential component of the coagulation cascade. Also known as Fibrin Stabilizing Factor (FSF), Factor XIII is an endogenously produced coagulation factor and the final enzyme within the blood coagulation cascade. Within the body, FXIII circulates as a heterotetramer composed of 2 A-subunits and 2 B-subunits (A2B2). Other products with similar structure and function to the product include Coagulation Factor XIII A-Subunit (Recombinant), which is a recombinant form of the A subunit of human coagulation factor XIII. Compared to the product , which is purified from pooled human plasma, Coagulation Factor XIII A-Subunit (Recombinant) is produced through recombinant DNA technology where the target protein is grown in yeast and then isolated.
• Sequences: Not Available
• Species: Human
• Molecular Weight: Not Available
• Formula: Not Available
• Endotoxin: <0.001 EU per 1 μg of the protein by the LAL method
• Biological Activity: 250U
• Application: The product, available as the commercially available product, is approved by the Food and Drug Administration for routine prophylactic treatment and peri-operative management of surgical bleeding in adult and pediatric patients with congenital FXIII deficiency.

Pharmaceutical Information

• Pharmaceutical Application: Factor XIII (human)