Dulanermin, Recombinant human Apo2L/TRAIL

Specification

• Cat#: THP-0297
• Product Name: Dulanermin, Recombinant human Apo2L/TRAIL
• Cas No: 867153-61-5
• Description: Dulanermin, a recombinant human soluble protein corresponding to amino acids 114-281 of the Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (RhApo2L/TRAIL) with potential antineoplastic activity. Dulanermin binds to and activates TRAIL receptors 1 and 2 (TRAIL-R1/R2), which may activate caspases and induce p53-independent apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors TRAIL-R1 and -R2, also known as DR4 (death receptor 4) and DR5 (death receptor 5), are members of the TNF receptor family and are overexpressed by a variety of cancer cell types.
• Species: Human
• Molecular Weight: 19.492 kDa
• Purity: >99% by SDS-Page and HPLC analysis
• Formula: C871H1329N243O260S4
• Endotoxin: <0.001 EU per 1 μg of the peptide by the LAL method
• Application: Treatment of metastatic non-small cell lung cancer.

Pharmaceutical Information

• Pharmaceutical Application: Dulanermin