Denenicokin, Recombinant human interleukin 21

Specification

• Cat#: THP-0306
• Product Name: Denenicokin, Recombinant human interleukin 21
• Description: Denenicokin, a recombinant peptide similar to or identical to endogenous human cytokine interleukin-21 (IL-21) with potential antineoplastic activity, binds to and activates IL-21 receptors, expressed on T-cells, B-cells, dendritic cells (DC), and natural killer (NK) cells, modulating the proliferation and/or differentiation of T and B cells, promoting T cell survival, and increasing the cytolytic activity of cytotoxic T lymphocytes (CTLs) and NK cells.
• Species: Human
• Molecular Weight: 15.580 kDa
• Purity: >99% by SDS-Page and HPLC analysis
• Cas No: 716840-32-3
• Formula: C676H1087N205O203S8
• Endotoxin Level: <0.1 EU per 1 μg of the peptide by the LAL method

Pharmaceutical Information

• Pharmaceutical Application: Denenicokin
• Applications: Metastatic or Recurrent Melanoma
• Examples of Clinical Use: Neoplasms by Site; Renal Cell Adenocarcinoma; Malignancies / Ovarian Cancer
• Targets: IL21R (CD360)