A mixture of antibodies used to treat venomous snake bites from Crotalus atrox (Western Diamondback rattlesnake). The product is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Crotalus atrox (Western Diamondback rattlesnake). The final purified antivenin product is produced by mixing other different monospecific snake antivenins and isolating the antivenin of interest through fractionation and chromatography techniques.
<0.001 EU per 1 μg of the peptide by the LAL method
Crotalus atrox antivenin
The product is indicated for the management of adult and pediatric patients with North American crotalid envenomation. The term crotalid is used to describe the Crotalinae subfamily (formerly known as Crotalidae) of venomous snakes which includes rattlesnakes, copperheads and cottonmouths/water moccasins.
Examples of Clinical Use:
Snake venom of rattlesnakes, copperheads and cottonmouths
Crotalus atrox venom contains agents that render human fibrinogen and plasma incoagulable by thrombin. The product reverses these effects.This facilitates re-distribution of venom toxins away from target tissues and elimination from the body.It is a mixture of 4 different monospecific antivenoms derived from serum of healthy sheep immunized with one of the following North American snake venoms: C. atrox (Western diamondback rattlesnake), C. adamanteus (Eastern diamondback rattlesnake), C. scutulatus (Mojave rattlesnake), or A. piscivorus (cottonmouth or water moccasin).
Mechanism of action:
CROFAB consists of venom-specific Fab fragments of immunoglobulin G (IgG) that work by binding to and neutralizing venom toxins, facilitating their redistribution away from target tissues and their elimination from the body.
For research use only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products
without prior written approval from Creative BioMart.
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