Bovine type I collagen

Specification

• Cat#: THP-0155
• Product Name: Bovine type I collagen
• Description: Bovine collagen alpha-1 is a naturally occurring extracellular matrix protein which is found in tendons and other connective tissues. It plays a vital role in cell growth, differentiation, attachment, and migration. Often combined with other ingredients, such as fibroblasts and keratinocytes, it allows for accelerated and effective wound healing.
• Sequences: Not Available
• Species: Bovine
• Molecular Weight: Not Available
• Cas No: 9050-08-2
• Formula: Not Available
• Endotoxin Level: <0.001 EU per 1 μg of the peptide by the LAL method

Pharmaceutical Information

• Pharmaceutical Application: Bovine type I collagen
• Applications: For the management of wounds including: partial and full- thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/graft, post-Moh’s dermatological surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns and skin tears) and draining wounds. Allogeneic Cultured Keratinocytes and Fibroblasts in Bovine Collagen is an allogeneic cellularized scaffold product indicated for topical (non-submerged) application to a surgically created vascular wound bed in the treatment of mucogingival conditions in adults. It uses bovine collagen as a matrix to support the growth of keratinocytes and fibroblasts in wound healing. Other products using bovine type 1 collagen include PriMatrix, Integra, Orcel and Matriderm. Orcel is a bilayered cellular matrix in which normal human allogeneic skin cells (both epidermal keratinocytes and dermal fibroblasts) are cultured in two separate layers into a Type I bovine collagen sponge, indicated in venous leg ulcers and diabetic foot. Type I bovine collagen acts as a matrix for the growth and proliferation of fibroblasts and keratinocytes, offering structure and support.In the laboratory, the product purified protein standard is used as a control for SDS-PAGE, Western Blot, ELISA, immunoprecipitation, and for other immunological assays.
• Examples of Clinical Use: Wounds
• Pharmacodynamics: Collagen-based ingredients are very important for tissue engineering and regenerative medicine because of its superior human biocompatibility and low immunogenicity. The product belongs to a family of proteins found particularly in the flesh and connective tissues of mammals (approximately 1/3 of the body's total protein). More than two dozen types of collagen have been discovered; Type I is the most abundant form in the body. This type of collagen is found in scar tissue, tendons, the skin, arterial wall, the cornea, muscles, cartilage, and in certain parts of bones and teeth. The product is ideal for investigators studying in extracellular matrix proteins and osteoporosis. Type I collagen is the primary organic component of the extracellular matrix in the bone and can play an imperative role in bone tissue engineering. Type I collagen (bovine) is the basis of several laboratory and pharmaceutical products including Collapat II, Healos, Collagraft, and Biostite, among others.
• Mechanism of action: Collagen is a fibrillar protein that forms the conjunctive and connective tissues in the human body, including the skin, joints, and bones. This molecule is one of the most predominant in many living organisms, owing to its connective role in biological structures.
• Affected organisms: Humans

Related Reading

1. Basic introduction of Bovine type I collagen

Bovine type I collagen is a kind of high-quality natural collagen. It is derived from cow skin, bone, tendon, and other tissues, and has many important biological functions and wide application value. It is one of the main components of connective tissue, but also a key component of the cornea, bone, cartilage, blood vessels, teeth, and other tissues, in addition, bovine collagen type I has good biocompatibility, biodegradability, and low immunogenicity, and other properties, so it has been widely used in the medical field.
In recent years, bovine collagen type I, as an important biological material, has been widely used in the preparation of human tissue repair and regeneration materials, medical elastoplastic surgical instruments, medical collagen membranes, dental materials, cosmetics, and so on. In addition, it is also widely used in food, feed, leather, and paper industries, and is a very valuable natural product.

2. Clinical application of Bovine type I collagen

Bovine type I collagen (Bovine Type I collagen) has many clinical applications and has been approved by FDA and other agencies. The following are some common application areas:
(1) Soft tissue repair and regeneration: Bovine collagen type I can be used to prepare biological materials, such as films, scaffolds, or gels, for soft tissue repair and regeneration. It can be used as a filling material to treat skin defects in patients with wounds, burns, ulcers, etc., and promote wound healing and tissue remodeling.
(2) Bone tissue repair and regeneration: Bovine collagen type I can be used to prepare bone tissue engineering scaffolds and artificial bone substitutes to promote the repair and regeneration of bone defects. It can provide supporting structures and bioactive substances to promote the growth of new bone and the bone healing process.
(3) Medical collagen membrane: Bovine type I collagen can be prepared into a film-like material for various applications in the medical field, such as medical dressing, wound dressing, surgical barrier film, etc. It has good biocompatibility and biodegradability, and can promote wound healing and tissue repair.
(4) Oral dental materials: Bovine collagen type I can be used to prepare periodontal soft tissue repair materials, such as soft tissue increment and gum transplantation, etc. It can be used to repair gingival receding and soft tissue defects after dental implantation.

3. Mechanism of action of Bovine type I collagen

The mechanism of action of Bovine type I collagen (Bovine Type I collagen) in clinical application mainly includes the following aspects:
(1) Cell signaling: Bovine collagen type I can bind to specific receptors on the cell surface and trigger intracellular signaling pathways. This signaling mechanism can activate biological processes such as cell proliferation, migration, and differentiation, and promote tissue repair and regeneration.
(2) Bionic scaffold: Bovine collagen type I can be used as scaffold material to provide the matrix structure required for cell adhesion and growth. Its special nanostructure and three-dimensional arrangement can simulate natural tissues, providing an ideal growth environment for cells and promoting tissue repair and regeneration.
(3) Insertion and release of bioactive molecules: Bovine type I collagen can be used as a carrier to embed and release bioactive molecules, such as growth factors and cytokines. These bioactive molecules can regulate cell proliferation, differentiation, and phenotype to further promote tissue repair and regeneration.
(4) Mechanical support and protection: Bovine collagen type I has certain mechanical strength and elasticity, which can provide mechanical support in the process of tissue repair and regeneration. It can protect the damaged area from external stimulation, maintain a suitable ecological environment, and help cell growth and tissue reconstruction.

4. Advantages and disadvantages of clinical application

Bovine type I collagen is a kind of collagen extracted from cow skin, which has the following advantages and disadvantages in clinical application:
Advantages:
(1) Good biocompatibility: Bovine type I collagen has high biocompatibility and can be well-compatible with human tissues, reducing the possibility of foreign body rejection.
(2) High biological activity: Because it is similar to the human body's collagen, Bovine type I collagen has good biological activity, which can promote cell proliferation and regeneration and provide a supporting structure in the process of wound healing.
(3) Strong plasticity: Bovine type I collagen has good plasticity and can be processed and shaped according to needs, which is suitable for different types of clinical applications, such as implants and filling materials.
Disadvantages:
(1) Potential infection risk: As Bovine type I collagen is extracted from cow skin, there is the potential risk of infectious pathogens, such as viruses and bacteria. Therefore, this risk needs to be reduced by strict handling and disinfection before use.
(2) May trigger an immune reaction: Although Bovine type I collagen has good biocompatibility in most people, it may trigger an immune reaction in some individuals, resulting in allergy or rejection.
(3) Limited resources: access to a large number of Bovine type I collagen may be limited, which may lead to high production costs or unstable supply.
In general, Bovine type I collagen has good biocompatibility and bioactivity in clinical applications, but there are also some potential risks and limitations. Before use, the individual situation and needs of the patient should be fully assessed and appropriate precautions taken to minimize the risk.