Bovine Thrombin

Specification

• Cat#: THP-0095
• Product Name: Bovine Thrombin
• Cas No: Not Available
• Description: Thrombin, Also known as coagulation factor II, is a serine protease that plays a physiological role in regulating hemostasis and maintaining blood coagulation. It is a protein substance produced through a conversion reaction in which prothrombin of bovine origin is activated by tissue thromboplastin in the presence of calcium chloride.
• Sequences: MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
• Species: Bovine
• Molecular Weight: Not Available
• Formula: Not Available
• Endotoxin: <0.001 EU per 1 μg by the LAL method
• Biological Activity: 5000IU/5ml
• Application: The product is indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (like suture, ligature, or cautery) is ineffective or impractical. Additionally, the product can also be used in combination with an absorbable gelatin sponge, USP.

Pharmaceutical Information

• Pharmaceutical Application: Thrombin
• Targets: Target 1. Proteinase-activated receptor 1; Target 2. Proteinase-activated receptor 4; Target 3. Coagulation factor XI; Target 4. Coagulation factor XIII A chain; Target 5. Coagulation factor XIII B chain; Target 6. Fibrinogen alpha chain; Target 7. Fibrinogen beta chain; Target 8. Fibrinogen gamma chain; Target 9. Coagulation factor V; Target 10. Coagulation factor VIII