This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains.
≥ 95% by SDS-PAGE gel and HPLC analyses.
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µg/ml.
Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects.
Examples of Clinical Use:
Augmenting periosteal repair of osteochondral defects.
BMP-13 (Bone Morphogenetic Protein 13), also known as GDF-6 (Growth Differentiation Factor 6), is a member of the bone morphogenetic protein family. The BMP-13 protein encodes a polypeptide protein that contains two conserved Cystein knot domains. BMP-13 protein belongs to the Bone Morphogenetic Protein Superfamily and is an important component of the skeletal system. It can regulate the growth and development of bone marrow stem cells, osteocytes, and chondrocytes, and plays an important role in bone regeneration in the body.
Function of BMP-13
The main function of BMP-13 is to regulate bone growth and maintenance, playing an important role in normal bone development. At the same time, it is also related to the proliferation and differentiation of chondrocytes and the formation of spinal segments. Experimental studies have shown that BMP-13 can promote the differentiation of bone marrow stem cells into osteoblasts, thereby promoting bone regeneration and repair.
BMP-13 related signaling pathway
The signaling pathway of BMP-13 protein is influenced by both extracellular and intracellular environmental factors. BMP-13 plays an important role in cell proliferation, differentiation, and bone growth by binding to receptors on the cell surface, activating the Smad signaling pathway, and initiating a series of downstream signaling pathways. When BMP-13 binds to its receptor BMPR-II, it can also activate various signaling pathways such as Akt, MEK/ERK, thereby regulating the growth and differentiation of bone cells and ultimately promoting the process of bone regeneration and repair.
BMP-13 related diseases
The functional defect of BMP-13 is associated with a variety of bone dysplasia and diseases. In recent years, studies have shown that BMP-13 plays an important role in the occurrence of skeletal muscle system diseases such as congenital hip dysplasia and iliac structural abnormalities. In addition, BMP-13 is also associated with the development and maintenance of the muscle and nervous system. For example, recent studies on BMP-13 have shown that it may be related to the prevention and treatment of neuromuscular diseases such as muscle atrophy.
Potential applications of BMP-13 protein in medicine
BMP-13 is widely used in clinical medicine and is one of the important means of reconstructing and repairing bone tissue. The application of BMP-13 can improve the growth vitality of bone cells by initiating bone marrow stem cell differentiation and regeneration, accelerating fracture healing, and shortening bone repair time, thereby promoting bone regeneration and repair. In addition, BMP-13 can be used in combination with other components for spinal fusion and prostate cancer treatment. The discovery and application of BMP-13 aims to cultivate, support, and promote the orthopedic industry, providing better treatment methods for patients.
Application of BMP-13 in drug research
BMP-13 also plays an important role in the process of drug research. In current research, targeted drug development has been made on the BMP-13 receptor, and certain achievements have been made in the treatment of muscle atrophy and neuromuscular diseases. At the same time, the combined application of BMP-13 and other growth factors has also become one of the focuses of research. For example, it has been found that the combined application of BMP-13 with growth factors such as IGF-1 and VEGF can reduce its toxicity to cells, while achieving more outstanding results, bringing broader development prospects for drug research, new drug development, and medical technology improvement.
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