Bone Morphogenetic Protein 1 (BMP1)

Specification

• Cat#: THP-0222
• Product Name: Bone Morphogenetic Protein 1 (BMP1)
• Description: Bone Morphogenetic Protein 1 (BMP1) produced primarily by E Coli or Yeast or Baculovirus or Mammalian Cell.
• Sequences: AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS DDTITKKGFH LRYTSTKFQD TLHSRK
• Species: Human
• Source: E Coli or Yeast or Baculovirus or Mammalian Cell
• Introduction: Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
• Purity: >90% as determined by SDS-PAGE. (lot specific)
• Formulation: Liquid containing glycerol

Pharmaceutical Information

• Applications: May participate in dorsoventral patterning during early development by cleaving chordin (CHRD)
• Examples of Clinical Use: Induces cartilage and bone formation.
• Affected organisms: Humans

Related Reading

1. Introduction of Bone Morphogenetic Protein 1 (BMP1)

Bone Morphogenetic Protein 1 (BMP1) is a zinc-dependent metalloprotease enzyme responsible for regulating extracellular matrix formation. BMP1 is involved in the metabolism of numerous extracellular matrix proteins such as collagens, osteonectin, and fibrillin, among others. It is also known to be involved in the process of bone formation and maintenance. BMP1 plays a critical role in the biosynthesis of the extracellular matrix, and disruptions in BMP1 activity have been implicated in several developmental disorders and diseases. Studies have suggested that BMP1 mutations can cause osteogenesis imperfecta, Ehlers-Danlos syndrome, and progressive pseudorheumatoid dysplasia, among other conditions. BMP1 represents an important target for both basic research and drug discovery efforts. Understanding the complex mechanisms by which BMP1 influences extracellular matrix formation can enhance our understanding of disease progression and potentially lead to the development of novel therapeutic interventions.

2．Structure and function of Bone Morphogenetic Protein 1 (BMP1)

Bone Morphogenetic Protein 1 (BMP1) belongs to the family of zinc metalloproteinases, which are enzymes characterized by the presence of a catalytic zinc ion at the active site. The structure of BMP1 consists of several domains that play vital roles in the enzyme's function. BMP1 consists of a signal peptide sequence that directs the enzyme to the endoplasmic reticulum, where it undergoes posttranslational modification. This is followed by a prodomain that acts as an inhibitor of the enzyme's catalytic activity and a conserved domain responsible for regulating substrate specificity. The catalytic domain of BMP1 is a homodimer composed of two identical chains, with each chain containing a zinc ion bound to the active site. The catalytic domain also contains a conserved portion called the HEXXHXXGXXH motif, which is involved in coordination of the catalytic zinc ion. A CUB (C1s, Uegf, BMP1) domain is also present in the BMP1 protein, which mediates protein-protein interaction and plays a crucial role in the secretion of BMP1. Additionally, BMP1 has a C-terminal region containing two CUB domains that are involved in substrate recognition and regulation.

Bone Morphogenetic Protein 1 (BMP1) is a protease enzyme that plays a crucial role in various biological processes such as extracellular matrix formation, collagen synthesis, tissue mineralization, embryonic development, and regulation of growth factors. BMP1 cleaves the C-terminal propeptides of procollagen molecules, thereby converting them into mature fibrillar collagen proteins which contribute to the strength and function of various organs including bones, skin, and tendons. BMP1 is also involved in tissue mineralization, the process of depositing calcium and other minerals in the bone matrix, which is essential for maintaining the skeletal structure and strength. In addition, BMP1 regulates the activity of other bone morphogenic proteins (BMP), which are involved in bone and cartilage development, cell differentiation, and immune cell function. BMP1 also plays a critical role during embryonic development by regulating the formation of various tissues and organs including bone, cartilage, and heart muscles. It is involved in cell differentiation, migration, and apoptosis, which are important processes for embryonic development.

3. Clinical application of Bone Morphogenetic Protein 1 (BMP1)

BMP1 has various clinical applications in medicine, some of which are:

1. Bone Growth and Repair: BMP1 is used clinically to promote bone growth and repair in patients suffering from osteoporosis, spinal fusion, and non-healing fractures. It is also used in bone grafting procedures to enhance bone regeneration and improve the success rates of the surgery.
2. Wound Healing: BMP1 is used in the treatment of chronic wounds such as diabetic foot ulcers. It stimulates the growth of new tissue and angiogenesis, promoting faster wound healing and reduced risk of infection.
3. Connective Tissue Disorders: Mutations in the BMP1 gene have been associated with various connective tissue disorders such as osteogenesis imperfecta, Ehlers-Danlos syndrome, and Marfan syndrome. Understanding BMP1's role in these disorders could lead to the development of new therapies.
4. Cancer: BMP1 has also been studied for its role in cancer progression and metastasis. Studies have shown that BMP1 expression is elevated in some cancers, and it promotes angiogenesis and the growth of new blood vessels to cancers. This information may be useful in the development of new cancer therapies.
5. Cardiovascular Disorders: BMP1 also plays a critical role in heart function and development. BMP1 has been linked to hypertension and pulmonary arterial hypertension (PAH), and its inhibition could provide a potential therapeutic target for these conditions.