Avotermin, Recombinant human TGF beta 3/TGFB3 Protein

Specification

• Cat#: THP-0318
• Product Name: Avotermin, Recombinant human TGF beta 3/TGFB3 Protein
• Description: Avotermin is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.
• Species: Human
• Purity: >95% by SDS-Page and HPLC analysis
• Cas No: 182212-66-4
• Endotoxin Level: <0.1 EU per 1 μg of the peptide by the LAL method
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 °C for 1 week. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Pharmaceutical Information

• Pharmaceutical Application: Avotermin
• Applications: Juvista has been investigated for the treatment, prevention, and basic science of Scars, Keloid, and Cicatrix.
• Examples of Clinical Use: After successful phase I/II trials, human recombinant TGF-β3 (Avotermin, planned trade name Juvista) failed in Phase III trials.
• Mechanism of action: Transforming growth factor beta3 stimulants