Asparaginase Erwinia chrysanthemi

Specification

• Cat#: THP-0055
• Product Name: Asparaginase Erwinia chrysanthemi
• Cas No: 1349719-22-7
• Description: The product contains an asparaginase specific enzyme derived from Erwinia chrysanthemi. Specifically, this L-asparaginase is a tetrameric enzyme consisting of four identical subunits, each having a molecular weight of about 35 kDa.
• Sequences: ADKLPNIVILATGGTIAGSAATGTQTTGYKAGALGVDTLINAVPEVKKLANVKGEQFSNMASENMTGDVVLKLSQRVNELLARDDVDGVVITHGTDTVEESAYFLHLTVKSDKPVVFVAAMRPATAISADGPMNLLEAVRVAGDKQSRGRGVMVVLNDRIGSARYITKTNASTLDTFKANEEGYLGVIIGNRIYYQNRIDKLHTTRSVFDVRGLTSLPKVDILYGYQDDPEYLYDAAIQHGVKGIVYAGMGAGSVSVRGIAGMRKAMEKGVVVIRSTRTGNGIVPPDEELPGLVSDSLNPAHARILLMLALTRTSDPKVIQEYFHTY
• Species: Erwinia chrysanthemi
• Molecular Weight: 140000.0 Da
• Purity: >95% by SDS-Page and HPLC analysis
• Formula: C1546H2510N432O476S9
• Endotoxin: <0.001 EU per 1 μg of the protein by the LAL method
• Biological Activity: 10000U
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 °C for 1 week. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Application: The product is for the treatment of patients with acute lymphoblastic leukemia (ALL) that have developed a hypersensitivity to E. coli-derivied asparaginase. It is a component of a multi-agent chemotherpeutic regimen for the treatment of the aforementioned disease and is considered second- or third- line treatment in European and American protocols.

Pharmaceutical Information

• Pharmaceutical Application: Asparaginase Erwinia chrysanthemi