Cat# : THP-0046
|THP-0046||Alpha-1-antitrypsin, Alpha-1-proteinase inhibitor||March 29, 2023||5mg||$800||
|Add to Cart Online Order Request a Bulk Order|
|Product Name:||Alpha-1-antitrypsin, Alpha-1-proteinase inhibitor|
|Description:||Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.|
|Molecular Weight:||44324.5 Da|
|Purity:||>99% by SDS-Page and HPLC analysis|
|Endotoxin Level:||<0.001 EU per 1 μg by the LAL method|
|Biological Activity:||25 mg / mL|
|Storage:||Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 °C for 1 week. Aliquots of reconstituted samples are stable at < -20°C for 3 months.|
|Drug Name:||Alpha-1-proteinase inhibitor|
|Applications:||For chronic augmentation and maintenance therapy in individuals with alpha1-proteinase inhibitor (A1-PI) deficiency and clinical evidence of emphysema.|
|Examples of Clinical Use:||Alpha1-proteinase inhibitor (A1-PI) deficiency|
|Pharmacodynamics:||Prevents excessive accumulation of active neutrophil elastase and consequent proteolysis of elastin tissues in alveolar lung structures. This prevents the development of emphysema.|
|Mechanism of action:||Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.|
|Affected organisms:||Humans and other mammals|
|Targets:||Target 1. Neutrophil elastase|
For more information on how our products could help advance your project, please contact us.
ENTER YOUR EMAIL HERE TO SUBSCRIBE.
Copyright © Creative BioMart. All Rights Reserved.