AG-858

Specification

• Cat#: THP-0811
• Product Name: AG-858
• Description: AG-858 (autologous heat-shock protein 70 peptide vaccine) is a recombinant cancer vaccine made with tumor-derived heat shock protein 70 (HSP70) peptide complexes. HSP70 associates with antigenic peptides, transporting them into antigen presenting cells (APC) for processing. Tumor-derived HSP70-peptide complexes used in vaccine preparations have been shown to prime tumor immunity and tumor-specific T cells in animal models.
• Cas No: Not Available

Pharmaceutical Information

• Pharmacodynamics: AG-858 is an investigational personalized vaccine designed to treat cancer while minimizing the side effects that are often associated with other treatment options. Patients undergo a blood-filtering process called leukapheresis, during which white blood cells are collected. The white blood cells are sent to Antigenics so that the personalized vaccines can be made. Vaccines provoke the body’s natural disease-fighting response. A vaccine that is made from the patient’s own cancerous cells is designed to contain the particular cancer’s ‘fingerprint.’ Injection of the AG-858 vaccine may cause the body to attack any cells bearing this cancer fingerprint.
• Mechanism of action: Under normal conditions, heat shock proteins are not found outside the cell. But if a cancerous or infected cell has become so sick that it dies and its membrane bursts, all of the cell’s contents spill out, including heat shock proteins that are bound to peptides. These extracellular HSPs send a very strong ‘dange r signal’ to the immune system, instructing it to destroy the other diseased cells.